These two technologies are disabled by default in most configurations.
To use Symantec Endpoint Protection 12.1 RU6 MP5 (and later versions of 12.1.x) with Windows 10 Anniversary Update, Microsoft Hypervisor Code Integrity (HVCI) and Microsoft Device Guard must remain disabled to avoid compatibility issues. Symantec Endpoint Protection 12.1 RU6 MP5 added basic compatibility support for Windows 10 Anniversary Update / Windows 10 Feature Update 1607. For more information on the release, see Symantec Endpoint Protection 14 Release Notes. Symantec Endpoint Protection 14 is fully supported on Windows 10 Anniversary Edition and Windows Server 2016. *Identifying Monetised Links - outgoing links that we monetise are marked with an '*' symbol.SEP 14 has full support for it: Compatibility with Windows 10 Anniversary Update and Windows Server 2016 One final thing, you do not need to worry about the lack of support for this security software, as support will be offered up until July 5, 2018. You will be able to Troubleshoot and Manage Threats, read and study Recommended Articles, look at the latest Alerts, and also take time reading through Documentation and Training. If you have been experiencing issues with 12.1.3, then you might want to visit the Endpoint Protection Technical Support page, as it gives you an array of information and support. 49, the sequence number 172303, and also the number of signatures 41,070,705. The new definitions were created on January 21, but was not released until today, Jan. There is a dedicated page for Symantec Endpoint Protection 12.1.3 (or later), where you have a range of support documents, and also the download for the latest definitions, which you can find here. 
You really need to make certain you are running this update because it offers the most secure, and up-to-date security content.
If you wish to stay secure while running Symantec Endpoint Protection, then you will want to download the latest update, which is definitions version 180121aw.
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